Why This Study Matters

L-ergothioneine is an antioxidant found in mushrooms. The body absorbs it through a unique pathway. A 2025 study tested if taking it daily can boost brain health, memory, and sleep in older adults.

Key Findings

Researchers tested healthy adults who noticed mild memory loss. Participants took 10 mg or 25 mg of L-ergothioneine daily or a placebo for 16 weeks. Those taking the pill saw clear gains:

• Better Focus & Memory: People taking 25 mg daily had better focus, mental speed, and memory recall.
• Better Sleep: Taking the pill helped people fall asleep faster and sleep better.
• Cell Protection: It helped protect DNA from normal aging stress.

How it works in the body:

• Cell Shield: It enters brain cells directly to fight stress at the source.
• Brain Support: It crosses into the brain to protect nerve cells and blood vessels.
• Long Lasting: The body holds onto it for a long time, so it stays active in your tissue.

Practical Takeaways

• Best Dose: Brain and sleep benefits were strongest at 25 mg per day.
• Easy to Take: You can take it with or without food.
• Eat Mushrooms: You can also get it by eating shiitake, maitake, porcini, or king oyster mushrooms.

Reference

The Effect of Ergothioneine Supplementation on Cognitive Function, Memory, and Sleep in Older Adults with Subjective Memory Complaints: A Randomized Placebo-Controlled Trial.